Symbol
Name
ID

Pitx2
paired-like homeodomain transcription factor 2
MGI:109340

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased response to growth hormone stimulation test	Abnormality of the hypothalamus-pituitary axis
Disease(s) Associated with PITX2	Decreased response to growth hormone stimulation test	Abnormality of the hypothalamus-pituitary axis
Axenfeld-Rieger syndrome
Axenfeld-Rieger syndrome type 1

Mouse Phenotypes

endocrine/exocrine gland phenotype

abnormal adenohypophysis morphology

abnormal adenohypophysis development

abnormal Rathke's pouch apoptosis

abnormal Rathke's pouch development

small Rathke's pouch

absent gonadotrophs

decreased somatotroph cell number

decreased thyrotroph cell number

adenohypophysis hypoplasia

abnormal pituitary gland development

pituitary gland hypoplasia

small thyroid gland

abnormal pancreas morphology

small testis

Availability

Mouse Genotype

Pitx2^tm1Hmd/Pitx2^tm1Hmd

Pitx2^tm1Rsd/Pitx2^tm1Rsd

Pitx2^tm1Sac/Pitx2^tm1Sac

Pitx2^tm2Sac/Pitx2^tm2Sac

Pitx2^tm1.1Dmm/Pitx2^tm2Sac

Pitx2^{tm1b(EUCOMM)Wtsi}/Pitx2⁺

Pitx2^tm1Sac/Pitx2^tm2Sac

Pitx2^tm1.1Sac/Pitx2^tm2Sac
Tg(Tshb-cre)4Sac/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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